- Introduction
- Anorexia Nervosa
- Bulimia Nervosa
- Binge-Eating
Disorder
- Treatment Strategies
- Research Findings
and Directions
- For More Information
- References
Introduction
Eating is
controlled by many factors, including appetite, food availability,
family, peer, and cultural practices, and attempts at voluntary
control. Dieting to a body weight leaner than needed for health
is highly promoted by current fashion trends, sales campaigns for
special foods, and in some activities and professions.
Eating disorders
involve serious disturbances in eating behavior, such as extreme
and unhealthy reduction of food intake or severe overeating, as
well as feelings of distress or extreme concern about body shape
or weight.
Researchers are
investigating how and why initially voluntary behaviors, such as
eating smaller or larger amounts of food than usual, at some point
move beyond control in some people and develop into an eating disorder.
Studies on the basic biology of appetite control and its alteration
by prolonged overeating or starvation have uncovered enormous complexity,
but in the long run have the potential to lead to new pharmacologic
treatments for eating disorders.
Eating disorders
are not due to a failure of will or behavior; rather, they are real,
treatable medical illnesses in which certain maladaptive patterns
of eating take on a life of their own.
The main types
of eating disorders are anorexia nervosa and bulimia nervosa. A
third type, binge-eating disorder, has been suggested but has not
yet been approved as a formal psychiatric diagnosis. Eating disorders
frequently develop during adolescence or early adulthood, but some
reports indicate their onset can occur during childhood or later
in adulthood.
Eating disorders
frequently co-occur with other psychiatric disorders such as depression,
substance abuse, and anxiety disorders. In addition, people who
suffer from eating disorders can experience a wide range of physical
health complications, including serious heart conditions and kidney
failure which may lead to death. Recognition of eating disorders
as real and treatable diseases, therefore, is critically important.
Females are much
more likely than males to develop an eating disorder. Only an estimated
5 to 15 percent of people with anorexia or bulimia4 and an estimated
35 percent of those with binge-eating disorder5 are male.
Anorexia Nervosa
An estimated 0.5
to 3.7 percent of females suffer from anorexia nervosa in their
lifetime.1 Symptoms of anorexia nervosa include:
- Resistance
to maintaining body weight at or above a minimally normal weight
for age and height
- Intense fear
of gaining weight or becoming fat, even though underweight
- Disturbance
in the way in which one's body weight or shape is experienced,
undue influence of body weight or shape on self-evaluation, or
denial of the seriousness of the current low body weight
- Infrequent
or absent menstrual periods (in females who have reached puberty)
People with this
disorder see themselves as overweight even though they are dangerously
thin. The process of eating becomes an obsession. Unusual eating
habits develop, such as avoiding food and meals, picking out a few
foods and eating these in small quantities, or carefully weighing
and portioning food.
People with anorexia
may repeatedly check their body weight, and many engage in other
techniques to control their weight, such as intense and compulsive
exercise, or purging by means of vomiting and abuse of laxatives,
enemas, and diuretics. Girls with anorexia often experience a delayed
onset of their first menstrual period.
The course and
outcome of anorexia nervosa vary across individuals: some fully
recover after a single episode; some have a fluctuating pattern
of weight gain and relapse; and others experience a chronically
deteriorating course of illness over many years. The mortality rate
among people with anorexia has been estimated at 0.56 percent per
year, or approximately 5.6 percent per decade, which is about 12
times higher than the annual death rate due to all causes of death
among females ages 15-24 in the general population. The most common
causes of death are complications of the disorder, such as cardiac
arrest or electrolyte imbalance, and suicide.
Bulimia Nervosa
An estimated
1.1 percent to 4.2 percent of females have bulimia nervosa in their
lifetime.1 Symptoms of bulimia nervosa include:
- Recurrent episodes
of binge eating, characterized by eating an excessive amount of
food within a discrete period of time and by a sense of lack of
control over eating during the episode
- Recurrent inappropriate
compensatory behavior in order to prevent weight gain, such as
self-induced vomiting or misuse of laxatives, diuretics, enemas,
or other medications (purging); fasting; or excessive exercise
- The binge eating
and inappropriate compensatory behaviors both occur, on average,
at least twice a week for 3 months
- Self-evaluation
is unduly influenced by body shape and weight
Because purging
or other compensatory behavior follows the binge-eating episodes,
people with bulimia usually weigh within the normal range for their
age and height. However, like individuals with anorexia, they may
fear gaining weight, desire to lose weight, and feel intensely dissatisfied
with their bodies.
People with bulimia
often perform the behaviors in secrecy, feeling disgusted and ashamed
when they binge, yet relieved once they purge.
Binge-Eating Disorder
Community
surveys have estimated that between 2 percent and 5 percent of Americans
experience binge-eating disorder in a 6-month period.5,7 Symptoms
of binge-eating disorder include:
- Recurrent episodes
of binge eating, characterized by eating an excessive amount of
food within a discrete period of time and by a sense of lack of
control over eating during the episode
- The binge-eating
episodes are associated with at least 3 of the following: eating
much more rapidly than normal; eating until feeling uncomfortably
full; eating large amounts of food when not feeling physically
hungry; eating alone because of being embarrassed by how much
one is eating; feeling disgusted with oneself, depressed, or very
guilty after overeating
- Marked distress
about the binge-eating behavior
- The binge eating
occurs, on average, at least 2 days a week for 6 months
- The binge eating
is not associated with the regular use of inappropriate compensatory
behaviors (e.g., purging, fasting, excessive exercise)
People with binge-eating
disorder experience frequent episodes of out-of-control eating,
with the same binge-eating symptoms as those with bulimia.
The main difference
is that individuals with binge-eating disorder do not purge their
bodies of excess calories. Therefore, many with the disorder are
overweight for their age and height. Feelings of self-disgust and
shame associated with this illness can lead to bingeing again, creating
a cycle of binge eating.
Treatment Strategies
Eating disorders
can be treated and a healthy weight restored. The sooner these disorders
are diagnosed and treated, the better the outcomes are likely to
be.
Because of their
complexity, eating disorders require a comprehensive treatment plan
involving medical care and monitoring, psychosocial interventions,
nutritional counseling and, when appropriate, medication management.
At the time of diagnosis, the clinician must determine whether the
person is in immediate danger and requires hospitalization.
Treatment of anorexia
calls for a specific program that involves three main phases: (1)
restoring weight lost to severe dieting and purging; (2) treating
psychological disturbances such as distortion of body image, low
self-esteem, and interpersonal conflicts; and (3) achieving long-term
remission and rehabilitation, or full recovery.
Early diagnosis
and treatment increases the treatment success rate. Use of psychotropic
medication in people with anorexia should be considered only after
weight gain has been established. Certain selective serotonin reuptake
inhibitors (SSRIs) have been shown to be helpful for weight maintenance
and for resolving mood and anxiety symptoms associated with anorexia.
The acute management
of severe weight loss is usually provided in an inpatient hospital
setting, where feeding plans address the person's medical and nutritional
needs. In some cases, intravenous feeding is recommended. Once malnutrition
has been corrected and weight gain has begun, psychotherapy (often
cognitive-behavioral or interpersonal psychotherapy) can help people
with anorexia overcome low self-esteem and address distorted thought
and behavior patterns. Families are sometimes included in the therapeutic
process.
The primary goal
of treatment for bulimia is to reduce or eliminate binge eating
and purging behavior. To this end, nutritional rehabilitation, psychosocial
intervention, and medication management strategies are often employed.
Establishment
of a pattern of regular, non-binge meals, improvement of attitudes
related to the eating disorder, encouragement of healthy but not
excessive exercise, and resolution of co-occurring conditions such
as mood or anxiety disorders are among the specific aims of these
strategies.
Individual psychotherapy
(especially cognitive-behavioral or interpersonal psychotherapy),
group psychotherapy that uses a cognitive-behavioral approach, and
family or marital therapy have been reported to be effective.
Psychotropic medications,
primarily antidepressants such as the selective serotonin reuptake
inhibitors (SSRIs), have been found helpful for people with bulimia,
particularly those with significant symptoms of depression or anxiety,
or those who have not responded adequately to psychosocial treatment
alone. These medications also may help prevent relapse.
The treatment
goals and strategies for binge-eating disorder are similar to those
for bulimia, and studies are currently evaluating the effectiveness
of various interventions.
People with eating
disorders often do not recognize or admit that they are ill. As
a result, they may strongly resist getting and staying in treatment.
Family members or other trusted individuals can be helpful in ensuring
that the person with an eating disorder receives needed care and
rehabilitation. For some people, treatment may be long term.
Research Findings and Directions
Research
is contributing to advances in the understanding and treatment of
eating disorders.
- NIMH-funded
scientists and others continue to investigate the effectiveness
of psychosocial interventions, medications, and the combination
of these treatments with the goal of improving outcomes for people
with eating disorders.8,9
- Research on
interrupting the binge-eating cycle has shown that once a structured
pattern of eating is established, the person experiences less
hunger, less deprivation, and a reduction in negative feelings
about food and eating. The two factors that increase the likelihood
of bingeing-hunger and negative feelings-are reduced, which decreases
the frequency of binges.10
- Several family
and twin studies are suggestive of a high heritability of anorexia
and bulimia,11,12 and researchers are searching for genes that
confer susceptibility to these disorders.13 Scientists suspect
that multiple genes may interact with environmental and other
factors to increase the risk of developing these illnesses. Identification
of susceptibility genes will permit the development of improved
treatments for eating disorders.
- Other studies
are investigating the neurobiology of emotional and social behavior
relevant to eating disorders and the neuroscience of feeding behavior.
- Scientists
have learned that both appetite and energy expenditure are regulated
by a highly complex network of nerve cells and molecular messengers
called neuropeptides.14,15 These and future discoveries will provide
potential targets for the development of new pharmacologic treatments
for eating disorders.
- Further insight
is likely to come from studying the role of gonadal steroids.16,17
Their relevance to eating disorders is suggested by the clear
gender effect in the risk for these disorders, their emergence
at puberty or soon after, and the increased risk for eating disorders
among girls with early onset of menstruation.
For More Information
Please visit
the following
link for more information about organizations that focus on eating
disorders.
References
- American
Psychiatric Association Work Group on Eating Disorders. Practice
guideline for the treatment of patients with eating disorders
(revision). American Journal of Psychiatry, 2000; 157(1 Suppl):
1-39.
- American
Psychiatric Association. Diagnostic and Statistical Manual for
Mental Disorders, fourth edition (DSM-IV). Washington, DC: American
Psychiatric Press, 1994.
- Becker AE,
Grinspoon SK, Klibanski A, Herzog DB. Eating disorders. New England
Journal of Medicine, 1999; 340(14): 1092-8.
- Andersen
AE. Eating disorders in males. In: Brownell KD, Fairburn CG, eds.
Eating disorders and obesity: a comprehensive handbook. New York:
Guilford Press, 1995; 177-87.
- Spitzer RL,
Yanovski S, Wadden T, Wing R, Marcus MD, Stunkard A, Devlin M,
Mitchell J, Hasin D, Horne RL. Binge eating disorder: its further
validation in a multisite study. International Journal of Eating
Disorders, 1993; 13(2): 137-53.
- Sullivan
PF. Mortality in anorexia nervosa. American Journal of Psychiatry,
1995; 152(7): 1073-4.
- Bruce B,
Agras WS. Binge eating in females: a population-based investigation.
International Journal of Eating Disorders, 1992; 12: 365-73.
- Agras WS.
Pharmacotherapy of bulimia nervosa and binge eating disorder:
longer-term outcomes. Psychopharmacology Bulletin, 1997; 33(3):
433-6.
- Wilfley DE,
Cohen LR. Psychological treatment of bulimia nervosa and binge
eating disorder. Psychopharmacology Bulletin, 1997; 33(3): 437-54.
- Apple RF,
Agras WS. Overcoming eating disorders. A cognitive-behavioral
treatment for bulimia and binge-eating disorder. San Antonio:
Harcourt Brace & Company, 1997.
- Strober M,
Freeman R, Lampert C, Diamond J, Kaye W. Controlled family study
of anorexia nervosa and bulimia nervosa: evidence of shared liability
and transmission of partial syndromes. American Journal of Psychiatry,
2000; 157(3): 393-401.
- Walters EE,
Kendler KS. Anorexia nervosa and anorexic-like syndromes in a
population-based female twin sample. American Journal of Psychiatry,
1995; 152(1): 64-71.
- Kaye WH,
Lilenfeld LR, Berrettini WH, Strober M, Devlin B, Klump KL, Goldman
D, Bulik CM, Halmi KA, Fichter MM, Kaplan A, Woodside DB, Treasure
J, Plotnicov KH, Pollice C, Rao R, McConaha CW. A search for susceptibility
loci for anorexia nervosa: methods and sample description. Biological
Psychiatry, 2000; 47(9): 794-803.
- Frank GK,
Kaye WH, Altemus M, Greeno CG. CSF oxytocin and vasopressin levels
after recovery from bulimia nervosa and anorexia nervosa, bulimic
subtype. Biological Psychiatry, 2000; 48(4): 315-8.
- Elias CF,
Kelly JF, Lee CE, Ahima RS, Drucker DJ, Saper CB, Elmquist JK.
Chemical characterization of leptin-activated neurons in the rat
brain. Journal of Comparative Neurology, 2000; 423(2): 261-81.
- Devlin MJ,
Walsh BT, Katz JL, Roose SP, Linkei DM, Wright L, Vande Wiele
R, Glassman AH. Hypothalamic-pituitary-gonadal function in anorexia
nervosa and bulimia. Psychiatry Research, 1989; 28(1): 11-24.
- Flanagan-Cato
LM, King JF, Blechman JG, O'Brien MP. Estrogen reduces cholecystokinin-induced
c-Fos expression in the rat brain. Neuroendocrinology, 1998; 67(6):
384-91.
NIH Publication No. 01-4901
Printed 2001
Posted: 05/06/2004
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This publication
was written by Melissa Spearing, Office of Communications
and Public Liaison, National Institute of Mental Health (NIMH).
Expert assistance was provided by NIMH Director Steven E.
Hyman, M.D., and NIMH staff members Bruce N. Cuthbert, Ph.D.,
Regina Dolan-Sewell, Ph.D., Benedetto Vitiello, Ph.D., Clarissa
K. Wittenberg, and Constance Burr. Editorial assistance was
provided by Margaret Strock and Lisa D. Alberts, also NIMH
staff members.
http://www.nimh.nih.gov/publicat/eatingdisorders.cfm
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